This draft Decree provides detailed provisions and guidance for the implementation of a number of articles of the Law on Chemicals No. 69/2025/QH15. It consists of 5 chapters and 32 articles, establishing a comprehensive regulatory framework for the management of chemical activities and hazardous chemicals contained in products and goods. This draft Decree aims to operationalize and strengthen the legal framework established under the Law on Chemicals No. 69/2025/QH15. It introduces mechanisms for classification mechanism, listing, and management of chemical including licensing, declaration, specialized database, inspection procedures, and response capacity) in order to minimize risks, protect public health, the environment, and national security; prevent loss and misuse (including use in criminal activity, production of chemical weapons, or manufacture of narcotics); and address regulatory gaps arising from the transition from previous regulations to the new Law in the context of increasingly complex chemical production and trade.