The notified technical guide, issued by the Public Health Institute of Chile (ISP), regulates the submission of efficacy studies for the registration of and amendment of health registration certificates for disinfectants and sanitizers for sanitary and household use under Supreme Decree No. 157/2005. The document defines test criteria, minimum requirements for test reports, and specific conditions based on the type of microbial action and field of application (hospital, food, livestock, aquaculture, among others), detailing internationally recognized analytical methodologies (AOAC UNE, ASTM, US-EPA) and revoking the previous exemption for products containing sodium hypochlorite.